AIM: To compare the influence of endolaser or cryotherapy on capsule contraction syndrome(CCS)following phaco-vitrectomy and intraocular lens implantation in patients with rhegmatogenous retinal detachment.

METHODS: A total of 244 eyes were enrolled in this retrospective analysis. The surgical approach was standard vitrectomy combined with phacoemulsification and intraocular lens(IOL)implantation simultaneously. There were 198 eyes underwent endolaser and 46 eyes underwent cryotherapy during the surgery. The main outcome measures were postoperative clinical outcomes including anatomical position of retina, the capsules and the position of IOLs and best corrected visual acuity(BCVA)at 1d, 1wk, 1, 2, 3, 6mo and 1a.

RESULTS: There were 6 eyes(3.0%)of CCS occurred in endolaser group and 5 eyes(10.9%)of CCS occurred in cryotherapy group. The different procedures during the surgery were significantly associated with the incidence of CCS(odds ratio: 0.256, P=0.021, 95%CI: 0.075-0.880).

CONCLUSION: Different procedures during phaco-vitrectomy surgery are significantly associated with the incidence of CCS. Endolaser is more beneficial than cryotherapy in preventing CCS following phaco-vitrectomy and intraocular lens implantation.