AIM:To investigate and compare the application of two screening models in the detection of retinopathy of prematurity(ROP).

METHODS: The clinical data of 600 premature infants(1200 eyes)who underwent screening of eye diseases in the Department of Ophthalmology during the period from January 2016 to January 2017 were analyzed retrospectively. The fundus lesions were examined with binocular indirect ophthalmoscope(BIO)and the third generation of wide-angle digital retinal imaging system(RetCam III). The examination results and adverse events during operation were statistically analyzed.

RESULTS: In 1200 eyes of 600 patients, the probabilities of ROP detected by BIO and RetCam III were 10.92% and 10.75%, respectively(P>0.05). With BIO as the golden standard, the accuracy, sensitivity, specificity, positive predictive value and negative predictive value of RetCam III in examining ROP were 98.67%, 93.13%, 99.35%, 94.57% and 99.16%, respectively. There was no significant difference in the stage of ROP detected by BIO or RetCam III(P>0.05). The probabilities of non-ROP lesions examined by BIO and RetCam III were 4.83% and 4.58%, respectively(P>0.05). With BIO as the golden standard, the accuracy, sensitivity, specificity, positive predictive value and negative predictive value of RetCam III in examining fundus non-ROP diseases were 99.67%, 94.83%, 99.91%, 98.21% and 99.74%, respectively. During the screening of BIO and RetCam III, there were 17 cases(2.83%)and 7 cases(1.17%)with adverse events, respectively(P<0.05).

CONCLUSION: The examination results of RetCam III are basically the same as those of BIO for ROP and non-ROP diseases. However, RetCam III has more advantages in reducing adverse events during operation.