AIM: To investigate the clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy(DR)with diabetic macular edema(DME).

METHODS: The clinical data of 50 patients(98 eyes)with DME treated in our hospital from March 2014 to March 2017 were retrospectively analyzed. Patients were randomly divided into two group, 25 patients(48 eyes)treated with macular grid laser photocoagulation were included into the control group. On the basis of this, 25 patients(50 eyes)treated with Qi Ming granule were included into observation group. The central macular thickness(CMT)and best corrected visual acuity(BCVA)between two groups were evaluated and compared after detected by optical coherence tomography(OCT)and fundus fluorescein angiography(FFA)at 7d, 1 and 3mo post-treatment.

RESULTS: The total effective rate was 94% in the observation group with 47 effective eyes, which was was significantly higher than 83% in the control group with 40 effective eyes(P<0.05). The BCVA was significantly improved in the two groups after treatment; the BCVA of the observation group was significantly higher than that of the control group after 7d, 1 and 3mo treatment, the difference was statistically significant(P<0.05). CMT in the two groups after treatment decreased significantly; the CMT of the observation group was significantly lower than that of the control group after 7d, 1 and 3mo treatment, with statistical significance(P<0.05). The intraocular hypertension occurred in observation group(2 eyes)and the control group(1 eyes), and relieved quickly after receiving medication, without any other obvious adverse reactions.

CONCLUSION: The clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy with macular edema is effective, which can reduce CMT, improve eyesight.