AIM: To compare the application effect on patients with retinopathy of prematurity(ROP)screened by wide-angle digital retinal imaging system(RetCam)and binocular indirect ophthalmoscope(BIO).

METHODS: Totally 1 624 cases(3 248 eyes)of premature infants were detected by RetCam and BIO in our hospital from May 2014 to May 2017. The screening results of ROP and occurrence of adverse events were compared between two checking methods.

RESULTS: In the 1 624 cases(3 248 eyes)of premature infants, 196 cases(392 eyes)of premature infants were detected by RetCam and 189 cases(378 eyes)of premature infants were detected by BIO, there was no statistical significance on staging results and partition pathological results between RetCam and BIO(P>0.05). Taking inspection result of BIO as standard, the sensibility, specificity, false positive rate and positive predictive value was 100.00%, 99.51%, 3.57% and 96.43%, respectively. The adverse event rate of RetCam and BIO was 0.18% and 0.22%, respectively, there was no statistical significance(P>0.05).

CONCLUSION: RetCam and BIO have similar application efficacy for screening ROP, and RetCam could take the place of BIO as the screening method of ROP.