AIM: To analyze the related risk factors for children's multiple chalazion.

METHODS: In experimental group, 300 cases(600 eyes)of children with multiple chalazion and the control group, 236 cases(472 eyes)of similar eye examination of the normal children in case-control studies, using Logistic regression method to analyze many factors to screen out the main risk factors.

RESULTS: By Logistic regression analysis, we found the meibomian gland function, tear secretion reduces, family history, constipation, partial eclipse, living environment were correlated with the occurrence of multiple meibomian gland cyst in children, and no significant correlation with visual acuity, blood cholesterol, trace elements, and bacterial infection.

CONCLUSION: The meibomian gland function, tear secretion reduce, family history, constipation, partial eclipse, living environment for children, are main risk factors for multiple chalazion. We should pay attention to those factors to prevent it.