目的：使用设备内置标准数据库，比较时域光学相干断层扫描仪(Stratus OCT)和频域光学相干断层扫描仪(Spectralis OCT)检测青光眼患者视网膜神经纤维层(RNFL)缺损的敏感性。

方法：该研究包括35例52眼开角型青光眼患者。已明确RNFL缺损的69例半视网膜(每一例OCT检查结果再次分为上方1/2和下方1/2)使用Stratus OCT的快速扫描和Spectralis OCT的环形扫描进行检测。使用设备内置数据库以RNFL厚度属于最低的5%人群或1%人群分别评估，以比较两种设备的诊断敏感性。

结果：在5%和1%两个水平上，Spectralis OCT在每一象限中均比Stratus OCT更多的检测到RNFL缺损(5%： 79.7% vs 63.8%， P=0.01； 1%： 56.5% vs 40.6%， P=0.01)。以1%异常水平，Spectralis OCT的标准扇形区域检测敏感性显著高于Stratus OCT的时钟数字区域(68.1% vs 39.1%， P <0.01)。

结论：使用设备内置数据库检测青光眼患者RNFL缺损时，Spectralis OCT各项参数的敏感性较Stratus OCT高。

METHODS: Fifty-two eyes of 35 patients with open angle glaucoma were included. A total of 69 hemiretinas with photographically identified RFNL defects were analyzed using the fast RNFL scan of Stratus OCT and the circle scan in Spectralis OCT. The OCT parameters were evaluated at 5% and 1% abnormality levels using the instruments' built-in normative databases. The diagnostic sensitivity of each parameter was compared between the two devices.

RESULTS: The Spectralis OCT detected RNFL defects within each quadrant more frequently than the Stratus OCT at both the 5%(79.7% vs 63.8%, P=0.01)and 1%(56.5% vs 40.6%, P=0.01)abnormality levels. At the 1% abnormality level, the sensitivity was significantly higher in the standard sector of Spectralis OCT than in the clock-hour sector of the Stratus OCT(68.1% vs 39.1%, P <0.01).

CONCLUSIONS: Using the instruments' built-in normative databases, the diagnostic sensitivity of the Spectralis OCT parameters was higher than that of the Stratus OCT parameters for detecting glaucomatous RNFL defects.