AIM: To investigate the relationship between adrenergic receptor(AR)R389G gene polymorphism and changes in intraocular pressure in patients with primary open angle glaucoma(POAG).

METHODS: We selected 100 patients with newly diagnosed POAG from January 2015 to February 2017 in our hospital. The patient's intraocular pressure was measured at 6:00, 12:00, 18:00, and 24:00 daily and the mean value was calculated. Patients with mean intraocular pressure ≥30mmHg were included in Group A(44 patients), patients with mean intraocular pressure <30mmHg were treated as Group B(56 patients). The clinical data of two groups of patients were compared, and multivariate Logistic regression analysis was used to investigate the relationship between β1AR R389G gene polymorphism and changes in intraocular pressure in patients with POAG.

RESULTS: The frequency of GG genotype in Group A(27.3%)was significantly higher than that in Group B(8.9%)(P<0.05). The allele G frequency was significantly higher in Group A(40.9%)than in Group B(18.8%), with a statistically significant difference(P<0.05). By multivariate Logistic regression analysis, increased systolic blood pressure and increased frequency of β1AR R389G allele were independent risk factors for increased intraocular pressure in POAG patients(P<0.05).

CONCLUSION: The β1AR R389G gene polymorphism is closely related to POAG and is an independent risk factor for increased intraocular pressure in patients with POAG.