AIM:To investigate the efficacy and safety of short-term application of pranoprofen eye drops in the treatment of dry eyes in senile patients.

METHODS: Totally 100 elderly patients with dry eyes treated in our hospital from June 2016 to May 2017 were randomly divided into 2 groups. All cases were bilateral onset, and the right eyes were marked as the observation eyes. The 50 eyes in the observation group were treated with 1g/L pranoprofen eye drops combined with 1g/L sodium hyaluronate eye drops, while 50 in the control group were treated with 1g/L sodium hyaluronate eye drops. The results of Schirmer Ⅰ, ocular surface disease index(OSDI), break-up time(BUT), ocular surface staining(OSS), human leukocyte antigen-DR(HLA-DR)and CD11b in conjunctival epithelial cells before and at 2wk after treatment, and adverse reactions in 2 groups were observed.

RESULTS: Before treatment, results of Schirmer I, OSDI, BUT, OSS, HLA-DR and CD11b in the two groups were similar, there were no statistically significant differences(P>0.05). After treatment, OSDI, OSS, HLA-DR, CD11b significantly decreased, BUT significantly increased in both groups, the differences were statistically significant(P<0.05). After treatment, OSDI, OSS and HLA-DR in the observation group were significantly lower than those in the control group, BUT in the observation group was significantly higher than those in the control group, the differences were statistically significant(P<0.01). The expression of HLA-DR was positively correlated with OSDI and OSS, and negatively correlated with BUT, and the correlations were statistically significant(P<0.05).

CONCLUSION: Short term application of pranoprofen eye drops can effectively enhance the efficacy in treating elderly patients with dry eyes, release clinical symptoms, and the therapeutic mechanism may be related to the inhibitory effect on HLA-DR.