AIM: To explore the application value of optic disc parameters and retinal nerve fiber layer(RNFL)thickness by swept source optical coherence tomography(SS-OCT)in the efficacy evaluation of primary angle-closure glaucoma(PACG).

METHODS: Totally 60 PACG patients(68 eyes)who was treated with peripheral iridotomy and trabeculectomy was selected. According to the intraocular pressure during postoperative follow-up, all the patients were divided into controlled group(<21mmHg, 39 cases 45 eyes), uncontrolled group(≥21mmHg, 21 cases 23 eyes). The SS-OCT was used to detect the RNFL thickness and optic disc parameters before and after treatment in both groups, and the therapeutic effect was evaluated.

RESULTS: The intraocular pressure in both groups were significantly reduced after treatment, and the controlled group was significantly lower than that in uncontrolled group(P<0.05). After treatment, the RNFL thickness in controlled group had not obvious difference compared with that before treatment(P>0.05), but it was obviously thinned in uncontrolled group compared with before treatment and control group(P<0.05). After treatment, disc area(DA)in uncontrolled group was increased obviously, and rim area(RA), rim volume(RV)was significantly reduced(P<0.05), and the optic disc parameters in controlled group were obviously better than those in uncontrolled group(P<0.05). Intraocular pressure was positively correlated with optic disc parameter DA, and negatively correlated with RA(r=0.415, -0.399; P<0.05).

CONCLUSION: SS-OCT can accurately reflect the change of optic disc parameters and RNFL thickness after intraocular pressure controlled in PACG patients. It has a certain clinical value in follow-up and efficacy evaluation for PACG.