AIM:To study the effect of Yijing Buyang Huanwu Decoction on intraocular pressure control and prognosis in patients with open angle glaucoma.

METHODS: Totally 93 patients(186 eyes)with open angle glaucoma admitted to our hospital from July 2015 to July 2017 were selected. All patients were divided into two groups according to the random number table method. In the observation group, 47 cases(94 eyes)were treated with timolol eye drop combined with Yijing Buyang Huanwu Decoction, and in the control group, 46 cases(92 eyes)were treated with timolol eye drop only. The clinical effect, visual acuity, intraocular pressure, central retinal artery blood flow, mean defect area, visual field average photosensitivity and image evoked visual potential were observed and compared before and after treatment.

RESULTS: The total effective rate of the observation group after treatment was significantly higher than that of the control group(85.1% vs 63.0%, P<0.01). After treatment, the intraocular pressure in the observation group was significantly lower than that in the control group(P<0.01). After treatment, RI values of central retinal artery blood flow in observation group were significantly lower than those in control group(P<0.01). PSA and EDV values were significantly higher than those in control group(P=0.011,<0.01). After treatment, the average photosensitivity of the observation group was significantly higher than that of the control group(P=0.001), and the average defect area was significantly less than that of the control group(P=0.011).

CONCLUSION: Yijing Buyang Huanwu Decoction is effective in the treatment of open angle glaucoma. It can effectively control the level of intraocular pressure, enlarge the visual field, promote blood circulation and improve the prognosis.