AIM: To investigate the correlation between erythrocyte immune function and serum erythropoietin(EPO)and plasma endothelin-1(ET-1)in patients with angle-closure glaucoma.

METHODS: Totally 30 patients with angle-closure glaucoma(case group)and 30 normal eyes(control group)were selected from our hospital from June 2017 to October 2017. The erythrocyte immune function, serum EPO and plasma ET-1 levels were measured and compared between the two groups.

RESULTS: The rosette rate of erythrocyte C3b receptor in the case group was significantly lower than that in the control group(10.81%±2.01% vs 18.06%±3.44%), the rosette rate of erythrocyte immune complex was significantly higher than that in the control group(17.21%±3.49% vs 11.74%±2.14%), the serum EPO concentration was significantly higher than that in the control group(26.10%±5.22mU/mL vs 22.68%±4.06mU/mL), and the plasma ET-1 concentration was significantly higher than that in the control group(70.85%±7.16ng/L vs 58. 43±5.09ng/L). The rosette rate of erythrocyte C3b receptor in patients with angle-closure glaucoma was positively correlated with serum EPO concentration(r=0.271, P<0.05), but not with plasma ET-1 concentration.

CONCLUSION: There is a positive correlation between erythrocyte immune function and serum EPO concentration in patients with angle-closure glaucoma.