目的：比较林格液和乳酸林格液(RL)在超声乳化术中作为冲洗液的差异，并探讨其对角膜内皮细胞的影响。

方法：这是一项前瞻性介入性双盲临床研究，包括100例(100眼)年龄在50～65岁之间的年龄相关性白内障患者。随机分为两组(每组各50眼)。组1使用林格液，组2使用乳酸盐林格液冲洗液。

结果：组1患者平均年龄57.5±8岁，组2患者平均年龄58.6±9岁。3mo后，组1内皮细胞密度平均下降8.5%，组2平均下降3.6%(P=0.013)。此外，组1中央角膜厚度平均增加6.9%，组2平均增加1.5%(P=0.006)。通过将测厚仪和高光显微镜参数的变化率与灌水量相关联得出两者间无显著相关性。

结论：与乳酸盐林格液相比，使用林格液作为冲洗液可减少术后内皮细胞的损失，也可减轻术后水肿。

METHODS: This was a prospective interventional double blinded clinical study that included 100 eyes of 100 patients aged between 50 to 65 years suffering from a visually significant age-related cataract and scheduled for routine uncomplicated phacoemulsification. The included eyes were randomly divided into two equal groups(each group included 50 eyes). Group 1 received Ringer's solution and group 2 received Ringer's lactate as an irrigating solution.

RESULTS: The first group with Ringer's solution had a mean age of 57.5±8 years and the second group with RL solution had a mean age of 58.6±9 years. After 3mo, endothelial cell density decreased in group 1 by a mean of 8.5%, and in group 2 by a mean of 3.6%(P=0.013). Additionally, central corneal thickness increased in group 1 by a mean of 6.9% and in group 2 by a mean of 1.5%(P=0.006). By correlating the percentage of change in pachymetry and specular microscopic parameters with volume of irrigation solution used, there was no significant correlation.

CONCLUSION: The use of Ringer's lactate as an irrigating solution is associated with less endothelial cell loss postoperatively in comparison to Ringer's solution and also associated with decreased postoperative edema.