Age-related macular degeneration(ARMD)is a major cause resulting in visual loss of middle-aged and older people. The exact cause of this disease is unknown yet, and the curative effect is poor. The lipofuscin accumulation in retinal pigment epithelium with age is the marker of eye aging, which produces effect on the function of normal retinal pigment epithelial cells through photochemical action and others. It is associated with the occurrence and development of ARMD to some extent. Lipofuscin and its relation with ARMD are comprehensively introduced in this paper.