AIM: To investigate the changes of ganglion cell-inner plexiform layer and retina thickness in myopic eyes after intraocular collamer lens(ICL)implantation using quantitative optical coherence tomography(OCT).

METHODS:A prospective study enrolled 41 myopic eyes of 26 patients which underwent ICL implantation(average age: 28.19±6.28 years). Aaxial length(AL), uncorrected visual acuity(UCVA), refractive diopter(RD), best corrected visual acuity(BCVA), intraocular pressure(IOP)and OCT were measured and compared in all patients before and after surgery. Optical coherence tomography(OCT)was used to image central retinal thickness(CRT)and ganglion cell-inner plexiform layer thickness(GCT). The changes between pre-and postoperative were analyzed by repeated measures analysis of variance(ANOVA). Least significant difference test was used to compare the specific time points after operation with those before operation.

RESULTS: Compared with the preoperative data, all the patients showed significant improvements in the postoperative UCVA and BCVA(P<0.05). However, there was no statistical significance in IOP. CRT were 273.20 ±25.48, 274.07±27.64, 277.85 ±25.49, and 275.99 ±24.68μm before and after surgery, respectively, while GCT were 85.31 ±5.19, 88.95±6.87, 87.73±4.23, and 87.45±4.59μm, respectively, with statistically significant changes(all P <0.05). Among them, CRT increased in one month after operation, with statistical significance(P<0.01). GCT increased in 1wk, 1mo and 3mo after operation, with statistical significance(P<0.05). The changes of GCT in 1wk after operation was positively correlated with AL(r_s=0.529, P=0.001).

CONCLUSION:ICL implantation for myopic eyes has good efficacy and safety, but macular area changes will occur after surgery, which need to be paid attention to.