[关键词]
[摘要]
青光眼滤过性手术失败最主要的原因是瘢痕化造成的滤过通道堵塞。增生的瘢痕中，Tenon囊成纤维细胞转化为肌成纤维细胞持续存在，并且分泌大量的细胞外基质，胶原纤维排列紊乱。国内外学者对青光眼滤过性手术后抗瘢痕治疗进行了大量的研究，现将青光眼滤过手术后瘢痕形成机制及对应的研究进展进行综述。
[Key word]
[Abstract]
Filtering channels carring and subsequent obstruction are the main cause of operation failure after glaucoma filtration surgery. During the process of scarring, human Tenon fibroblasts are transformed into myofibroblasts and secrete a large amount of extracellular matrixproteins. The derangement of the collagen fiber is also observed. A large number of studies have been carried out by domestic and foreign researchers on the treatment of postoperative filtering channel scarring. In this review we summarize the mechanisms of scar formation after glaucoma filtration surgery and corresponding research progress in recent years.
[中图分类号]
[基金项目]
江苏省自然科学基金资助项目(No.BK20161287)
