Central serous chorioretinopathy(CSC)is a disease that associated with multifactors. The specific pathogenesis is not yet clear. Except for subthreshold micropulse laser treatment and reduced dose photodynamic therapy(PDT), drugs based on etiology of CSC, such as anti-vascular endothelial growth factor(VEGF), methotrexate, eplerenone, anti-helicobacter pylori, have been applied to experimental treatment. The purpose of this article is to review the literature in the treatment of CSC, and to provide reference for clinical treatment of CSC.