Congenital hypertrophy of the retinal pigment epithelium(CHRPE)is a rare fundus lesion. It usually does not cause serious clinical symptoms. However, incorrect diagnosis and treatment frequently occurred clinically because most ophthalmologists have little knowledge about it. Thus, we conducted the current study to investigate the clinical characteristics and prognosis of CHRPE, to provide evidence for differential diagnosis clinically and further guideline for treatment and follow-up.