AIM: To study the optical coherence tomography(OCT)treatment of optic fiber thickness in patients with high myopia combined with glaucoma.

METHODS: Totally 160 eyes of 80 patients with high myopia and glaucoma who were treated in our hospital during 2017-01/12 were selected as the observation group, and 60 healthy volunteers(120 eyes)who underwent physical examination in our hospital during the same period were selected as the control group. OCT was used to analyze the thickness of optic nerve fibers in both groups.

RESULTS: Subjects compared with control group, the observation group of patients with nasal side, temporal, under the nose, nasal, under the temporal and the week on the average thickness of the optic nerve fiber layer is reduced, and the temporal side nerve fiber layer thickness increased(P<0.05), and in the observation group diopter -10.00 to -11.00D in patients with nasal side, temporal, under the nose, nose, and the temporal and the week, on average, the optic nerve fiber layer thickness were significantly higher than that of diopter≥-12.00D patients(P<0.05). Spearman correlation analysis results showed that the absolute value of diopter was negatively correlated with the mean thickness of optic nerve fiber layer in the nasal side, upper temporal quadrant, lower nasal side, upper nasal side, lower temporal and the whole circumference, and positively correlated with the thickness of optic nerve fiber layer in the lateral temporal optic nerve.

CONCLUSION: In patients with high myopia combined with glaucoma, the optic nerve fibers in all quadrants except the temporal side become thinner.