[关键词]
[摘要]
视神经炎(ON)是由各种原因引起的视神经炎性病变，是中青年人最易罹患的致盲性视神经疾病。特发性视神经炎(ION)以经典多发性硬化相关性视神经炎(MS-ON)和视神经脊髓炎相关性视神经炎(NMO-ON)最常见。ION起病急、易复发，视功能损害较重，炎症是ION的一个重要的发生机制。细胞因子是一类具有调控免疫系统作用的小分子可溶性多肽的统称，促炎细胞因子(proinflammatory cytokines)通过介导炎症反应、参与免疫应答，在ION发病机制中的作用引起越来越广泛的关注。本文通过查阅国内外相关文献，就促炎细胞因子在ION发病机制中的作用最新研究作一综述，以推进ION发病机制和诊疗的深入研究。
[Key word]
[Abstract]
Optic neuritis(ON), which is the blinding optic nerve diseases that the young and middle-aged population are most susceptible to, is an optic neuropathy caused by various factors. Idiopathic optic neuritis(ION)occurs most frequently asmultiple sclerosis related optic neuritis(MS-ON)and neuromyelitis optica related optic neuritis(NMO-ON). ION has the characteristics of acute onset, easy recurrence, and serious dysfunction. Inflammation is an important mechanism of ION. By mediating inflammatory responses and participating in immune responses, proinflammatory cytokines, as one of cytokines which is a general term for a class of small molecule soluble peptides that regulate the immune system, have caused widespread concern in the pathogenesis of ION. This article reviews and discusses researches on the pathogenesis of proinflammatory cytokines-mediated ION at home and abroad in an effort to promote an in-depth study of the pathogenesis, diagnosis and treatment of ION.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No. 81574029)
