目的：观察新型中央孔型有晶状体眼后房型人工晶状体(ICL)V4c植入术矫正高度近视术后前房角的变化。

方法：前瞻性临床研究。选择高度近视患者150例300眼，均行ICL V4c植入术，记录术前及术后1d，1、3、6mo，1a的视力、眼压、拱高及前房角的变化。采用重复测量方差分析及LSD-t检验对数据进行分析。

结果：术后1d，1、3、6mo，1a，裸眼视力(UCVA)恢复情况较术前显著提高(F=98.2，P<0.01)； 术前与术后各时间点鼻侧AOD500、AOD750、TISA500、TISA750、SSA比较均有差异(F=108.256、112.342、164.856、316.549、115.338，均P<0.01)； 术前与术后各时间点颞侧AOD500、AOD750、TISA500、TISA750、SSA比较均有差异(F=102.68、548.47、93.37、316.549、117.698，均P<0.01)； 两侧术后1d，1、3mo各房角参数逐渐降低，两两比较均有差异(P<0.05)，术后3、6mo，1a各房角参数两两相比均无差异(P>0.05)。

结论：ICL V4c植入术后1d，1、3、6mo，1a水平方向各房角参数较术前变小，3mo后基本趋于稳定状态。

METHODS: Prospective study. ICL V4c implantation was performed on 150 cases(300 eyes)with high myopia, and the changes of visual acuity, intraocular pressure,vault and anterior chamber angle were recorded before and 1d, 1mo, 3mo, 6mo and 1a after operation. Repeated measurement analysis of variance and LSD-t test were used to analyze the data.

RESULTS: After 1d, 1mo, 3mo, 6mo, 1a operation, the recovery of UCVA was significantly higher than that before operation(F=98.2, P<0.01); there were statistically significant differences in AOD500, AOD750, TISA500, TISA750 and SSA of nasal side before and after operation(F=108.256, 112.342, 164.856, 316.549, 115.338, P<0.01); there were statistically significant differences in AOD500, AOD750, TISA500, TISA750 and SSA of temporal side before and after operation(F=102.68, 548.47, 93.37, 316.549, 117.698, all P<0.01); the parameters of each angle decreased gradually in the 1d, 1mo and 3mo after operation on both sides, and there was statistical difference in the two comparisons(all P<0.05), but there was no statistical significance in the parameters of each angle in the 3mo, 6mo and 1a after operation(all P>0.05).

CONCLUSION: After ICL V4c implantation, the anterior chamber angle parameters in the horizontal direction of 1d, 1mo, 3mo, 6mo and 1a were smaller than those before operation, and tended to be stable after 3mo.