AIM: To compare the clinical effects of two brands of Toric intraocular lens(IOL)used in surgical correction of cataract with corneal astigmatism.METHODS: Totally 35 patients(50 eyes)with corneal astigmatism who underwent ophthalmic surgery from April 2019 to July 2019 were retrospectively analyzed. Among them, 25 eyes of 20 patients were implanted with Rayner 623T, while 25 eyes of 15 patients with Alcon AcrySof Toric IOL. Three months after surgery, the uncorrected distance visual acuity(UCDVA), best corrected distance visual acuity(BCDVA), residual astigmatism, rotational degree of intraocular lens, contrast sensitivity, objective visual quality and the National Eye Institute 25-Item Visual Function Questionnaire(NEI VFQ-25)scale score were compared. Vector analysis was performed using the Alpins method.RESULTS: The mean postoperative UCDVA(LogMAR)and BCDVA(LogMAR)in the Rayner group were 0.17±0.20 and 0.08±0.15, respectively(P>0.05), while those in the Alcon group were 0.21±0.16 and 0.10±0.11, respectively(P>0.05). The mean residual astigmatism in the Rayner group was(-0.57±0.24)D while that in the Alcon group was(-0.50±0.28)D(P>0.05). There was no statistically significant difference between the two groups in IOL rotational stability, vector analysis parameters, contrast sensitivity and objective visual quality(P>0.05). The NEI VFQ-25 scale score was 85.16±5.91 in the Rayner group while it was 82.08±6.16 in the Alcon group(P>0.05).CONCLUSION: The two brands of Toric IOL-Rayner 623T and Alcon AcrySof Toric showed no significant difference in their clinical outcomes.