目的：评估分离格栅视觉诱发电位(IC-VEP)在诊断开角型青光眼中的表现，并将其与蓝黄色视野检查法(B/YP)和光学相干断层扫描(OCT)进行比较。方法：通过回顾性分析，对来自中国的101例受试者(正常组35例； 早期青光眼30例，中晚期青光眼患者36例)分别进行IC-VEP、蓝黄色视野检查和OCT等检查。计算IC-VEP、视野检查法和OCT对检测青光眼的敏感度以及这三种方法之间的一致性，以评估其临床表现。结果：早期POAG组的IC-VEP、蓝黄色视野检查和OCT的敏感度分别为70.00%、70.00%、63.33%。在中晚期POAG组中，IC-VEP、OCT和蓝黄色视野检查的敏感度分别为86.11%、88.89%、91.67%。其中IC-VEP的特异性为91.43%。IC-VEP的结果与OCT和蓝黄色视野测试高度一致(kappa：0.721～1.000，P<0.05)。结论：作为视觉功能的客观检查手段，IC-VEP可用于青光眼的早期诊断，也可用于监测可疑青光眼患者的RGC功能。

AIM: To evaluate the diagnostic performance of the isolated-checked visual evoked potential(IC-VEP)in the detection of open angle glaucoma and compared it to the blue-yellow perimetry(B/YP)and optical coherent tomography(OCT).METHODS: In a retrospective analysis, IC-VEP, perimetry and OCT were performed on 101 subjects(n=35, normal; n=30, early glaucoma; n=36, moderate and advanced glaucoma)from China. The sensitivity of IC-VEP, perimetry and OCT for detection of glaucoma, as well as the agreement within these 3 methods, were calculated to evaluate their clinic performance.RESULTS: In the early primary open angle glaucoma(POAG)group the sensitivity of IC-VEP, blue-yellow perimetry and OCT were 70.00%, 70.00% and 63.33%, respectively. In the moderate advanced POAG group, the sensitivity of IC-VEP, OCT and blue-yellow perimetry were 86.11%, 88.89% and 91.67%, respectively. The specificity of IC-VEP was 91.43%. The results of IC-VEP were highly consistent with OCT and blue-yellow visual field tests(kappa: 0.721-1.000, P<0.05).CONCLUSION:As an objective examination of visual function, IC-VEP can be used for early diagnosis of glaucoma. It may be a useful tool for monitoring the function of RGCs in suspected glaucoma patients.

湖南省临床医疗技术创新引导计划(No.2017SK50903); 爱尔眼科医院集团科研基金(No.AF1906D1); 深圳市知识创新计划基础研究项目(No.JCYJ20170307155030786)