Toll样受体(toll-like receptors，TLRs)是连接先天性免疫与获得性免疫的桥梁。随着对干眼发病机制研究的不断深入，TLRs及信号通路在干眼免疫应答中的诱导和调控作用日益受到关注。目前的研究表明，对TLRs及信号通路的调控有助于减轻或阻止干眼炎症反应过程，因此对TLR信号通路的调节及控制在干眼的治疗及预防中有重要的意义。本文总结TLRs及其信号通路参与干眼发病机制，不同干预方法对干眼TLR通路的影响，并对未来发展的前景及问题进行探讨。

Toll-like receptors(TLRs)are bridges of innate and acquired immunity. With the deepening of the research on the pathogenesis of dry eye, the induction and regulation of TLRs and signaling pathways in the immune response to dry eye have attracted more and more attention. Current studies have shown that the regulation of TLRs and signaling pathways helps to reduce or prevent the inflammatory response process in dry eye, so the regulation and control of TLR signaling pathways in the treatment and prevention of dry eyes has important significance. In this paper, TLRs and their signaling pathways are summarized in the pathogenesis of dry eye, and the effects of different intervention methods on the TLR pathway of dry eye are discussed, and the future development prospects and problems are also discussed.

山西省自然科学基金课题(No.201801D121356)