AIM: To explore the characteristic changes of multifocal electroretinogram(mfERG)in strabismic amblyopia eyes with eccentric fixation.

METHODS: A total of 20 patients with strabismus amblyopia and eccentric fixation visited our hospital from January 2018 to December 2020 were collected as the study group(4 patients with exotropia and 16 patients with esotropia), while 20 patients with ametropic amblyopia were collected as the control group. The mfERG was examined under the state of mydriasis, and the amplitude density and incubation period of P1 wave were recorded.

RESULTS: Compared with the fellow eyes, the first ring(P=0.001), the second ring(P<0.001), the third ring(P=0.001), the fourth ring(P=0.009)and the fifth ring(P=0.026)of strabismus amblyopia eyes were reduced significantly. Compared with the control group, the first ring(P=0.033), the second ring(P=0.002), the third ring(P<0.001)and the fourth ring(P=0.014)of strabismus amblyopia eyes were reduced significantly. The incubation period of amblyopia eyes in the strabismus group showed significantly shortened in the first ring(P=0.017)and the second ring(P=0.001)compared with the fellow eyes, and in the second ring(P=0.007)compared with the control group.

CONCLUSION: The amplitude density of mfERG P1 wave in strabismic amblyopia eyes with eccentric fixation reduced more with the closer to macular fovea, and reduced more significantly than that in the ametropic amblyopia eyes.