目的：研究正常眼压性青光眼(NTG)视盘区血管密度变化与青光眼视野指数(VFI)和视野损伤形态分期的关系。方法：选取我院2018-12/2020-12 NTG患者106例106眼和原发性开角型青光眼(POAG)患者79例79眼进行横断面研究，其中双眼病变者采用随机数字表选取1眼为样本，同时选取我院健康体检者92名为对照组，三组均完成视盘血管密度、VFI检测和视野缺损形态分期，然后分析视盘血管密度与VFI和视野缺损形态分期的关系。结果：POAG组眼压明显高于NTG组和对照组(P<0.05)； NTG组和POAG组视盘区全区域血管密度、大血管密度和毛细血管密度均明显低于对照组(P<0.05)，无血管区密度均明显高于对照组(P<0.05)，且NTG组和POAG组各项指标比较有差异(P<0.05)； NTG组和POAG组VFI均明显低于对照组(P<0.05)，视野平均缺损(MD)明显高于对照组(P<0.05)，且NTG组和POAG组VFI和MD比较无差异(P>0.05)； 随着视野缺损形态分期增加，NTG患者视盘全区域血管密度和毛细血管密度呈明显降低趋势(P<0.05)； NTG患者视盘全区域血管密度和毛细血管密度与VFI呈正相关性，与视野缺损形态分期呈负相关性，无血管区密度与VFI呈负相关性，与视野缺损形态分期呈正相关性(均P<0.05)。结论：NTG患者视盘血管密度较POAG患者和正常人群明显降低，且与VFI和视野缺损形态分期存在明显相关性，其中以毛细血管密度相关程度最高，可见OCTA对NTG诊断、治疗和随访均具有重要临床意义。

AIM: To study the relationship between the changes of blood vessel density in optic disc area of normal tension glaucoma(NTG)and visual field index(VFI)of glaucoma and morphological staging of visual field defect. METHODS: Totally 106 patients(106 eyes)with NTG and 79 patients(79 eyes)with primary open angle glaucoma(POAG)in the hospital between December 2018 and December 2020 were selected for cross-sectional study. Among them, 1 eye of binocular disease was selected as the sample by the random number table method, and another 92 healthy subjects with physical examination in the hospital were selected as control group. All three groups completed the optic disc blood vessel density, VFI detection and visual field defect morphological staging, and the relationship between optic disc blood vessel density and VFI and visual field defect morphological staging were analyzed.RESULTS: The intraocular pressure in POAG group was significantly higher than that in NTG group and control group(P<0.05). The whole optic disc area blood vessel density, large vessel density and capillary density of NTG group and POAG group were significantly lower than those of control group(P<0.05)while the density of avascular area was significantly higher than that of control group(P<0.05), and there were differences in various indicators between NTG group and POAG group(P<0.05). The VFI of NTG group and POAG group was significantly lower than that of control group(P<0.05)while the mean visual field defect(MD)was significantly higher than that of control group(P<0.05), and there were no statistical differences in VFI and MD between NTG group and POAG group(P>0.05). With the increase in visual field defect morphology staging, the whole optic disc area blood vessel density and capillary density of patients with NTG showed a significant decrease(P<0.05). The whole optic disc area blood vessel density and capillary density of patients with NTG were positively correlated with VFI and negatively correlated with visual field defect staging, and avascular area density was negatively correlated with VFI and positively correlated with visual field defect staging(all P<0.05). CONCLUSION:Optic disc blood vessel density of patients with NTG is significantly lower than that of patients with POAG and normal people, and it is significantly correlated with VFI and visual field defect morphological staging. Among them, capillary density has the highest correlation. It can be seen that OCTA has important clinical significance for NTG diagnosis, treatment and follow-up.