[关键词]
[摘要]
Netrin-1是神经轴突的导向因子，为一种由细胞底板分泌的可溶性蛋白，属于Netrins家族中研究最为广泛的一员。Netrin-1具有受体多样性，其与不同的受体结合可以激活不同的生物学效应，从而发挥多种功能。近年来研究发现，Netrin-1与神经轴突导向、炎症反应、新生血管形成、细胞凋亡等反应密切相关，不仅可在中枢神经系统发挥作用，还与许多系统疾病如呼吸道系统、心血管系统等疾病有关，使其成为治疗这些疾病的重要靶点。在眼科领域，Netrin-1与视神经发育不全(ONH)、角膜疾病、糖尿病视网膜病变(DR)、年龄相关性黄斑变性(ARMD)、视网膜母细胞瘤(RB)等疾病紧密联系，且在预防及治疗这些疾病中具有非常广阔的应用前景。在本篇综述中，我们将探讨Netrin-1与眼科疾病的联系及其作用。
[Key word]
[Abstract]
Netrin-1 is a neuronal axon guidance factor, a soluble protein secreted by the cell floor, and is among the most widely studied members of the Netrins family.Netrin-1 has the diversity of receptors, and its binding to different receptors can activate different biological effects, resulting in multiple functions. Recent studies have revealed that Netrin-1 is closely associated with neural axon guidance, inflammatory responses, neovascularization, apoptosis, and other responses. It can act not only in the central nervous system, but also in many systemic diseases such as those of the respiratory and cardiovascular systems, making it an important target for the treatment of these diseases. In the field of ophthalmology, Netrin-1 is closely associated with optic nerve hypoplasia(ONH), corneal disease, diabetic retinopathy(DR), age-related macular degeneration(ARMD), and retinoblastoma(RB), and has very promising applications in the prevention and treatment of these diseases. In this review, we will explore the association of Netrin-1 with ocular diseases and its role.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81760172,81760178); 广西自然科学基金项目(No.2018GXNSFAA281128)
