AIM:To observe the near stereoscopic visual function of adolescents with different degrees of myopic anisometropia after being corrected by spectacles and orthokeratology.

METHODS:In this prospective clinical research,220 patients aged 10-20 years old with myopic anisometropia were recruited between March 2017 and December 2018. All the patients were divided into four groups according to the difference of cycloplegic spherical equivalent refractive(SER)error between the two eyes: group of 76 cases without anisometropia(SER error difference less than 1.00D), group of 60 cases with mild anisometropia(SER error difference of 1.00-<1.75D), group of 51 cases with moderate anisometropia(SER error difference of 2.00-<2.75D), and group of 33 cases with severe anisometropia(SER error difference of 3.00D or more). With regards the different optical correction approaches for myopia, 88 cases were categorized into the orthokeratology group and 132 cases into the spectacle group, the stereoacuity values at 3mo after correction were compared between the orthokeratology group and the spectacle group to see whether statistically significant difference existed.

RESULTS:In the group of spectacle correction, there was significant statistical difference existed between the four sub-groups for the near stereoscopic visual function(P<0.001). In the group of orthokeratology correction, there was no statistical difference existed between the four sub-groups for the near stereoscopic visual function(P=0.765). In both non-anisometropia and mild anisometropia groups, there was no statistical difference between the orthokeratology correction and spectacle correction sub-groups for the near stereoacuity values(P=0.109,P=0.052). However, in the moderate and severe anisometropia groups, orthokeratology group had better near stereoscopic vision than spectacle group(P<0.001).

CONCLUSION: Adolescents with myopic anisometropia corrected by orthokeratology lens were better at near stereoscopic visual function than corrected by spectacles, especially in the moderate and severe anisometropia groups.