Uveitis is a common and refractory inflammatory blinding disease involving the uvea, retina, retinal vessels, and vitreous body. Its occurrence is related to the imbalance of immune mechanisms in various cell subpopulations. Macrophages play a central role in the body's innate immune system and can effectively clear pathogenic bacteria from the body. In stress responses, macrophages can participate in the body's pathogen response and inflammation regulation through polarization. Therefore, in order to systematically understand the important role of macrophage polarization balance in the immune regulation mechanism of uveitis, this article mainly links it with the occurrence and development of uveitis disease through the study of the source recognition of macrophages and the mechanism pathway, and finally summarizes the progress of related diagnosis and treatment.