目的：探索新生儿视网膜渗出样改变与围产期TORCH感染的关系以及视网膜渗出样改变患儿的TORCH感染特点。

方法：回顾性研究。选取2019-05/2023-03在我院行眼底病变筛查发现视网膜渗出样改变并进行TORCH检测的新生儿共612例，按照性别、月龄分组，对其TORCH检测的结果进行统计学分析，明确其感染特点，并比较各组的阳性率。

结果：612例新生儿视网膜渗出样改变的TORCH检测结果中，巨细胞病毒(CMV-IgG)阳性率最高(96.7%)，其次为风疹病毒(RV-IgG)，阳性率(73.9%)。可存在两种及三种病毒的混合感染，其中混合感染IgG阳性率最高达71.2%(RV-IgG和CMV-IgG)。不同性别的新生儿渗出样改变TORCH感染差异性无统计学意义(P>0.05)。不同月龄的新生儿渗出样改变TORCH感染中RV-IgG和CMV-IgM差异具有统计学意义(P<0.05)。

结论：围产期TORCH感染可能为引起新生儿视网膜渗出样改变的重要因素。各种感染的差异与性别无关，与不同月龄相关。

METHODS: Retrospective study. A total of 612 neonates with retinal exudative changes detected during ophthalmic screening in our hospital from May 2019 to March 2023 were selected. TORCH tests were performed on these neonates, and the results were subjected to statistical analysis to determine the infection characteristics. The neonates with retinal exudative changes were grouped by sex and age, the characteristics of TORCH infection were analyzed, and the positive rates were compared.

RESULTS: Among the 612 neonates with retinal exudative changes, the highest positive rate was observed for cytomegalovirus(CMV-IgG)(96.7%), followed by rubella virus(RV-IgG)(73.9%). Mixed infections with two or three viruses were also observed, with the highest positive rate for mixed infection of RV-IgG and CMV-IgG reaching 71.2%. There was no statistically significant difference in TORCH infection among neonates of different sex(P>0.05). However, there were statistically significant differences in RV-IgG and CMV-IgM infections with retinal exudative changes among neonates of different age groups(P<0.05).

CONCLUSION: Perinatal TORCH infection may be an important factor causing retinal exudative changes in neonates. The differences in various infections are not related to sex but are related to different age groups.