[关键词]
[摘要]
慢性阻塞性肺疾病(COPD)是一组以持续性气流受限为特征的肺部疾病，这种疾病常伴有慢性缺氧，进而导致全身血管壁结构和功能改变并引起血管反应性损伤。视网膜和脉络膜作为眼部重要结构，具有丰富血流灌注，极易因缺血缺氧而发生微结构变化。光学相干断层扫描(OCT)作为观察这种微结构变化的理想工具，能无创、非侵入性地评估视网膜各层微结构和微血管病理改变。目前尚缺乏关于COPD患者眼底OCT形态改变的研究总结，文章详细回顾了当前有关COPD患者眼底OCT形态变化的研究，重点探讨了视网膜和脉络膜在结构与血流方面的变化，旨在概括COPD对眼底微结构的影响，探索这些形态学变化的潜在机制，并为COPD患者的眼底病变评估提供新的思路与见解。
[Key word]
[Abstract]
Chronic obstructive pulmonary disease(COPD)is a group of lung diseases characterized by persistent airflow limitation, often accompanied by chronic hypoxia. This chronic hypoxia can lead to structural and functional changes in the walls of blood vessels throughout the body, causing vascular injury and altered vascular reactivity. The retina and choroid are key ocular structures with rich blood supply and are particularly prone to microstructural changes due to ischemia and hypoxia. Optical coherence tomography(OCT), an ideal tool for observing these microstructural changes, serves as a non-invasive method for assessing retinal microstructures and microvascular pathology. Currently, there is a lack of comprehensive reviews summarizing OCT-based morphological changes in the eyes of COPD patients. This paper provides an in-depth review of existing studies on ocular OCT in COPD patients, focusing on structural and blood flow changes in the retina and choroid. The primary goal of this review is to summarize the impact of COPD on ocular microstructures, explore the underlying mechanisms of these morphological changes, and offer new perspectives for assessing eye diseases in COPD patients.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No. 82271102); 深圳市可持续发展科技专项项目(No. KCXFZ20211020163813019); 深圳市优秀科技创新人才培养项目(No. RCBS20210706092347043)
