Members of the Sirtuin(SIRT)family are class III histone deacetylases(HDAC Ⅲ)homologous to yeast silencing information regulator 2(Sir2), which mediates histone and non-histone deacetylation in a NAD⁺-dependent manner. Diabetic cataract(DC)is one of the most important complications of diabetes, which can lead to visual impairment and blindness. With the in-depth study of the Sirt1 signaling pathway, it is found that this signaling pathway plays an important role in the occurrence and development of DC, and this article reviews the research progress of Sirt1 in DC by examining its impact on different pathogenesis.