目的：通过文献计量学方法，分析国际上对眼表菌群的研究现状、研究热点和发展趋势。

方法：以Web of Science数据库为来源检索眼表菌群相关文献，对数据进行筛选、去重。对纳入的文献从发文量趋势、作者、机构、研究热点等进行文献计量分析，运用Cite Space软件完成机构/国家合作、文献被引、关键词共现、关键词聚类、关键词突现的可视化分析。

结果：最终纳入3 884篇文献，2003-2023年间眼表菌群领域的发文量总体呈上升趋势，以2019-2022年增长最为迅速。发文量排名前3的地区/国家分别是美国(1 039篇)、中国(570篇)、印度(302篇)； 发文量排名前3的作者分别是Willcox Mark(48篇)、Sharma Savitri(33篇)、Fleiszig Suzanne MJ(27篇)； 发文量排名前3的机构均来自美国，分别是加州大学、Prasad LV眼科研究所、哈佛大学。文献被引网络图谱包括801个节点，1 508条连线，被引频次居首位的文献为Temporal Stability and Composition of the Ocular Surface Microbiome。出现频次排名前5的关键词依次是keratitis(角膜炎)、bacterial flora(细菌群落)、identification(鉴定)、inflammation(炎症)、endophthalmitis(眼内炎)。关键词聚类分析后共得到8个聚类，具体体现在眼部相关疾病、眼表菌群与眼表结构、眼表菌群的检测手段3个方面。突现强度最大的关键词是ciprofloxacin(环丙沙星)； 最近几年突现并持续至今的关键词有diversity(多样性)、gut microbiome(肠道菌群)、ocular surface microbiome(眼表菌群)。

结论：目前国际上对眼表菌群的研究正逐渐呈上升趋势，其研究热点集中在菌群多样性，核心菌群组成及疾病影响等方面。未来应着眼于明确眼表菌群的功能代谢，深入研究眼表菌群变化与疾病之间的因果关系以及作用机制。

METHODS: Leveraging the Web of Science database, we conducted a targeted literature search on ocular surface flora. The retrieved data were meticulously screened and weighted to enhance relevance. The bibliometric analysis delved into publication trends, authorship patterns, institutional collaborations, and pivotal research themes. Employing Cite Space software, we visually dissected the landscape of institutional and national partnerships, citation impact, keyword co-occurrences, keyword clustering dynamics, and the emergence of new research trends.

RESULTS: A total of 3 884 publications were ultimately included, with an overall upward trend in the number of publications in the field of ocular surface microbiota from 2003 to 2023, with the most rapid growth occurring from 2019 to 2022. The top three regions/countries by publication volume are the United States(1 039 papers), China(570 papers), and India(302 papers). The top three authors by publication volume are Willcox Mark(48 papers), Sharma Savitri(33 papers), and Fleiszig Suzanne M.J(27 papers). The top three institutions by publication volume, all from the United States, are the University of California, L.V. Prasad Eye Institute, and Harvard University. The citation network map of the literature includes 801 nodes and 1 508 connections, with the most frequently cited document being Temporal Stability and Composition of the Ocular Surface Microbiome. The top 5 keywords by frequency of occurrence are, in order, keratitis, bacterial flora, identification, inflammation, and endophthalmitis. The keyword clustering analysis yielded a total of 8 clusters, which are specifically reflected in three aspects: ocular-related diseases, the relationship between ocular surface microbiota and ocular surface structures, and detection methods for ocular surface microbiota. The keyword with the highest burst strength is ciprofloxacin. Keywords that have emerged in recent years and continue to the present include diversity, gut microbiome, and ocular surface microbiome.

CONCLUSION: Currently, the study of ocular surface microflora is gaining momentum globally, with a particular focus on the diversity of microflora, the composition of the core microbiome, and its impact on ocular diseases. In the future, research should concentrate on elucidating the functional metabolism of the ocular surface microflora and further investigate the causality and mechanisms by which changes in the ocular surface microflora are related to diseases.