目的：探讨强脉冲光(IPL)联合育阴润目方熏蒸及睑板腺按摩治疗睑板腺功能障碍(MGD)相关干眼患者的效果。

方法：前瞻性研究。选取2021-11/2023-11本院收治的MGD相关干眼患者198例396眼，随机分为对照组99例198眼采用育阴润目方熏蒸及睑板腺按摩治疗，观察组99例198眼在对照组基础上联合IPL治疗。比较两组患者疗效以及治疗前后眼部指标\〖泪膜破裂时间(BUT)、泪液分泌量(SⅠt)\〗、视觉质量\〖平均客观散射指数(OSI)、斯特列尔比(SR)、调制传递函数(MTF)\〗、泪膜脂质层厚度(LLT)、泪液中炎性因子\〖肿瘤坏死因子-α(TNF-α)和转化生长因子-β1(TGF-β1)\〗的水平变化情况。

结果：所有患者均完成治疗及随访。 与治疗前比较，治疗2 mo后两组患者BUT、SⅠt、SR、MTF、LLT水平升高，OSI、泪液中TNF-α、TGF-β1水平降低(均P<0.001)，且观察组均优于对照组(均P<0.001)。

结论：IPL联合育阴润目方熏蒸及睑板腺按摩治疗MGD相关干眼的效果显著，可以改善患者眼部指标、视觉质量和LLT，降低泪液中炎性因子的水平。

METHODS: Prospectively selected 198 cases(396 eyes)of MGD-related dry eye patients admitted to our hospital from November 2021 to November 2023, and they were randomly divided into 99 cases(198 eyes)in control group treated with fumigation of Yuyin Runmu formula and meibomian gland massage, and 99 cases(198 eyes)in observation group treated with combined IPL on the basis of the control group. The efficacy of the two groups was compared, as well as the changes in the levels of ocular indexes \〖tear film break-up time(BUT), Schirmer I test(SⅠt)\〗, visual quality \〖objective scattering index(OSI), Strehl ratio(SR), and modulation transfer function(MTF)\〗, lipid layer thickness(LLT)of the tear film, and changes in tear fluid levels of inflammatory factors \〖tumour necrosis factor-α(TNF-α)and transforming growth factor-beta 1(TGF-β1)\〗.

RESULTS: All the patients completely received the treatment and follow-up. The levels of BUT, SⅠt, SR, MTF, and LLT increased and the levels of OSI, TNF-α, and TGF-β1 decreased in the two groups at 2 mo after treatment(all P<0.001), and the observation group was more favourable(all P<0.001).

CONCLUSION: IPL combined with Yuyin Runmu formula fumigation and meibomian gland massage is effective in treating MGD-related dry eye, improving patients' ocular parameters, visual quality, and LLT, and decreasing the levels of inflammatory factors in the tear fluid.