[关键词]
[摘要]
沉默信息调节因子相关酶1(SIRT1)是一种重要的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性去乙酰化酶，近年来在眼科研究中引起了广泛的关注。其原因在于，SIRT1在眼部组织中的表达及其功能，与干眼、青光眼、白内障和糖尿病视网膜病变等诸多眼科疾病的发病机制及进展有着不可分割的联系。通过深入探索，我们发现SIRT1作为一种关键的调控蛋白，能够通过调控细胞凋亡程序、调节氧化应激反应、介导炎症反应以及维护线粒体功能正常等多种机制，对眼科疾病的病理生理过程产生深远影响。这些发现揭示了SIRT1在眼科疾病中具有重要的保护作用。文章旨在全面综述近年来SIRT1在眼科疾病领域的最新研究成果，并期望通过深入剖析SIRT1的作用机制，为眼科疾病的预防和治疗提供新的思路和方法。
[Key word]
[Abstract]
The sirtuin 1(SIRT1)is an important NAD+-dependent deacetylase that has attracted much attention in ophthalmic research in recent years. This is because the expression of SIRT1 in ocular tissues and its function are inextricably linked to the pathogenesis and progression of many ocular diseases, including dry eye, glaucoma, cataract and diabetic retinopathy. Through in-depth investigations, we have found that SIRT1, as a key regulatory protein, has a profound impact on the pathophysiological processes of ocular diseases through a variety of mechanisms, such as regulating apoptotic programs, modulating oxidative stress, mediating inflammatory responses and maintaining normal mitochondrial function. These findings indicate that SIRT1 plays an important protective role in ocular diseases. The aim of this article is to comprehensively review the latest research findings on SIRT1 in ophthalmic diseases in recent years, and hopes to provide new ideas and methods for the prevention and treatment of ophthalmic diseases by thoroughly analyzing the mechanism of action of SIRT1.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81870643)
