[关键词]
[摘要]
真菌性角膜炎是一种高发的致盲性疾病，当前的治疗效果仍不理想。该疾病的发生和进展通常受到真菌毒力及宿主免疫反应的显著影响。在疾病进程中，先天性免疫反应首先被激活，其中中性粒细胞在抗真菌过程中发挥关键作用。虽然中性粒细胞在清除病原体方面具有重要功能，但是其过度或异常激活可能引发组织损伤，从而加重病情。因此，探究中性粒细胞在真菌性角膜炎中的作用机制，对于优化治疗策略至关重要。文章旨在综述中性粒细胞的主要杀菌机制，包括吞噬作用、脱颗粒、中性粒细胞胞外诱捕网(NETs)的形成，并探讨中性粒细胞与巨噬细胞的相互作用，以及其在真菌性角膜炎中的效应及潜在机制。对于真菌性角膜炎机制探究，有利于施行的精准干预并增强其治疗效果。
[Key word]
[Abstract]
Fungal keratitis represents a significant cause of blindness, with current therapeutic approaches yielding limited success. The disease's onset and progression are primarily driven by fungal virulence factors and the host's immune response. The innate immune system is the first to respond, with neutrophils playing a pivotal role in the antifungal defense. Although neutrophils are critical for pathogen clearance, their excessive or abnormal activation can lead to tissue damage, exacerbating the disease. Thus, elucidating the mechanisms underlying neutrophil activity in fungal keratitis is crucial for refining treatment strategies. This article aims to systematically review the principal antimicrobial mechanisms employed by neutrophils, including phagocytosis, degranulation, and the formation of neutrophil extracellular traps(NETs). Furthermore, it explores the crosstalk between neutrophils and macrophages, alongside their collective impact and underlying mechanisms in the context of fungal keratitis. Exploration of the mechanisms of fungal keratitis facilitates precise intervention and enhances the efficacy of treatment.
[中图分类号]
[基金项目]
海南省卫生健康科技创新联合项目(No.WSJK2024MS128); 海南省临床医学研究中心项目(No.LCYX202406); 海南省重点研发项目(No.ZDYF2022SHFZ326)
