[关键词]
[摘要]
近年来，随着角膜交联技术的发展，使用核黄素和紫外线的角膜交联疗法已越来越广泛地应用于眼科疾病领域，其适应证不仅适用于圆锥角膜等角膜扩张症，还扩展到各类感染性角膜炎、角膜化学伤、大泡性角膜病变和屈光手术等。角膜交联疗法作为治疗角膜疾病的非侵入性的干预方法，具有创伤小、恢复快、操作简单、安全性高等优点。文章旨在介绍角膜交联疗法的作用机制，重点阐明角膜交联疗法应用新进展，以及在治疗感染性角膜炎、化学烧伤、大泡性角膜病变、边缘性角膜病变等非扩张性角膜疾病中的疗效和安全性，有望有助于多种非扩张性角膜疾病治疗。
[Key word]
[Abstract]
In recent years, with the development of corneal cross-linking technology, corneal cross-linking therapy combined with adopting riboflavin and ultraviolet has been widely used in several corneal disorders, not only for keratoconus, but also for other corneal diseases, including infectious keratitis,chemical corneal injury, bullous keratopathy, and refractive surgery. Corneal cross-linking is a non-invasive procedure with the virtue of minor damage, rapid rehabilitation, convenient operation, and high safety. This review aims to investigate the mechanism of corneal cross-linking therapy, emphasizing the new progress of its efficacy and safety in the application of treating non-expanding corneal diseases, including infectious keratitis, chemical burns, bullous keratopathy and marginal degeneration. Corneal cross-linking therapy may be potentially helpful in the treatment of non-expanding corneal diseases.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No.82171062)
