[关键词]
[摘要]
N6-甲基腺苷(m6A)是哺乳动物中最常见的mRNA修饰，几乎参与所有涉及mRNA代谢的过程，包括RNA转录、翻译和降解，在生物各种生理活动中起着重要作用。在甲基转移酶、去甲基化酶和m6A结合蛋白三者协同作用下，m6A修饰可发生可逆性地改变，发挥其分子功能。甲基转移酶样3(METTL3)蛋白是甲基转移酶的核心催化亚基，是目前研究最广泛的甲基转移酶，在m6A修饰中起着核心作用。近年来，研究发现METTL3介导m6A修饰通过影响炎症因子的表达从而调控炎症反应，调控各种通路影响细胞增殖及氧化应激等生物过程，参与眼部各种疾病如眼表疾病、青光眼、白内障、视网膜疾病及眼部肿瘤的发生与发展。文章综述METTL3在眼部疾病中的作用机制，为眼部疾病防控提供新思路。
[Key word]
[Abstract]
N6-methyladenosine(m6A)is recognized as the most prevalent mRNA modification in mammals, intricately involved in a multitude of processes pertaining to mRNA metabolism, encompassing RNA transcription, translation, and degradation. It plays a pivotal role in various physiological functions. Under the coordinated actions of methyltransferases, demethylases, and m6A-binding proteins, m6A modifications undergo reversible changes to fulfill their diverse molecular functions.Methyltransferase-like 3(METTL3), as the core catalytic subunit of methyltransferases and the most extensively studied methyltransferase, holds a central position in m6A modification. In recent years, it has been found that METTL3-mediated m6A modification is involved in the occurrence and development of various ocular diseases, such as ocular surface diseases, glaucoma, cataract, retinal diseases, and ocular tumors, by affecting the expression of inflammatory factors and thus regulating the inflammatory response, and by regulating various pathways that affect the proliferation of cells and oxidative stress. In this paper, we comprehensively review the mechanisms under the role of METTL3 in ocular diseases, offering novel insights and perspectives for the prevention and management of these conditions.
[中图分类号]
[基金项目]
四川省科技厅自然科学基金项目(No.2023NSFSC0595); 川北医学院附属医院科研发展计划重点项目(No.2023ZD010)
