[关键词]
[摘要]
正常眼压性青光眼(NTG)是一种以进行性视神经损伤和视野缺损为特征的慢性眼病，其发病机制与遗传、免疫炎症以及血管因素密切相关。光学相干断层扫描血管成像技术(OCTA)作为一种无创、实时的影像学工具，能够定量分析眼底血流变化。近年来，OCTA在NTG中的研究与应用不断深入，显示出其在早期诊断以及疾病监测和管理等方面具有重要价值。文章系统总结OCTA在NTG中的最新研究，重点探讨了NTG患者视盘和黄斑区域血流的OCTA表现，并进一步总结了OCTA在NTG诊断和监测管理中的应用进展。此外，还评估了当前OCTA技术的局限性以及其在临床应用中面临的挑战，并对其未来发展进行了展望，以期为NTG的血管发病机制研究及OCTA在临床应用中的推广提供理论依据和参考。
[Key word]
[Abstract]
Normal tension glaucoma(NTG)is a chronic optic neuropathy characterized by progressive damage to the optic nerve and visual field defects, with its pathophysiology closely linked to genetic, immune-inflammatory and vascular factors. Optical coherence tomography angiography(OCTA)is a noninvasive imaging technique that provides real-time, quantitative assessment of retinal microvascular perfusion. In recent years, OCTA has been increasingly applied in NTG studies, demonstrating significant potential in early diagnosis, disease monitoring and management. This systematic review summarizes the latest advancements in the application of OCTA for NTG, with a focus on vascular parameters in the optic nerve head and macular regions. Its diagnostic value and monitoring management are further summarized. Moreover, the current limitations of OCTA technology and the challenges related to its clinical application are critically evaluated, while exploring its future developments. These insights aim to provide a theoretical foundation for further research on NTG-related microvascular pathology and the broader clinical application of OCTA.
[中图分类号]
[基金项目]
江苏省高等学校大学生创新训练计划项目(No.202410312086Y)
