[关键词]
[摘要]
视网膜血管性疾病(RVD)是全球主要致盲疾病之一,RVD的患病率呈现逐年增长的趋势。其中年龄相关性黄斑变性(ARMD)、糖尿病性黄斑水肿(DME)和视网膜静脉阻塞(RVO)最为常见的类型。Faricimab由罗氏公司的CrossMAB平台研发,是一种能够同时靶向并抑制血管内皮生长因子-A(VEGF-A)和血管生成素-2(Ang-2)的新型双特异性单抗。Faricimab对这两个关键因子的双重抑制,使其具备了更全面、更有效地调节血管生成和炎症反应的潜力,为RVD的治疗带来了新的契机。
[Key word]
[Abstract]
Retinal vascular diseases(RVD)are among the leading causes of blindness worldwide, with their prevalence showing an increasing trend year by year. Among them, age-related macular degeneration(ARMD), diabetic macular edema(DME), and retinal vein occlusion(RVO)are the most common types. Faricimab, developed by Roche's CrossMAB platform, is a novel bispecific monoclonal antibody that can simultaneously target and inhibit vascular endothelial growth factor-a(VEGF-A)and angiopoietin-2(Ang-2). The dual inhibition of these two key factors by Faricimab endows it with the potential to regulate angiogenesis and inflammatory responses more comprehensively and effectively, thus bringing new opportunities for the treatment of RVD.
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