目的：探究养阴益气汤联合聚乙二醇滴眼液治疗白内障术后干眼的临床效果及对泪液中炎症因子水平的影响。

方法：前瞻性研究。选取于2022年4月至2024年3月本院收治的白内障术后干眼患者104例104眼，随机分为两组：对照组52例52眼采用聚乙二醇滴眼液治疗； 联合组52例52眼采用养阴益气汤联合聚乙二醇滴眼液治疗。比较两组患者治疗前后干眼症状评分、泪膜稳定性指标、泪液炎症因子水平、眼表疾病指数评分(OSDI)及临床疗效。

结果：本研究中6例6眼失访，各组失访3例3眼，失访率为5.8%。联合组治疗总有效率显著高于对照组(94%vs 80%，P=0.037)，治疗后联合组患者泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)均高于对照组(均P<0.05)，干眼症状评分、角膜荧光素染色(FL)评分、泪液中IL-1β、TNF-α、hs-CRP水平及OSDI评分均低于对照组(均P<0.05)。

结论：养阴益气汤联合聚乙二醇滴眼液治疗白内障术后干眼可有效缓解患者干眼症状，减少眼部不适，提高泪膜稳定性及眼表状态，并降低泪液中炎症因子水平。

METHODS:Prospective study. A total of 104 patients(104 eyes)with dry eye disease after cataract surgery admitted to our hospital from April 2022 to March 2024 were selected and randomly divided into two groups: 52 cases(52 eyes)in the control group were treated with polyethylene glycol eye drops; 52 cases(52 eyes)in the combined group were treated with Yangyin Yiqi Decoction combined with polyethylene glycol eye drops. The dry eye symptom score, tear film stability index, tear inflammatory factor level, ocular surface disease index score(OSDI)and clinical efficacy of the two groups were compared before and after treatment.

RESULTS:There were 6 cases(6 eyes)lost to follow-up, and 3 cases(3 eyes)were lost to follow-up in each group, with a loss to follow-up rate of 5.8%. The total effective rate of treatment in the combination group was significantly higher than that in the control group(94% vs 80%, P=0.037), and the Schirmer I test(SIt)and tear film break-up time(BUT)were higher than those in the control group(all P<0.05), and the dry eye symptom score, corneal fluorescein staining(FL)score, IL-1β, TNF-α, hs-CRP levels in tears and OSDI score were lower than those in the control group(all P<0.05).

CONCLUSION:The combination of Yangyin Yiqi Decoction and polyethylene glycol eye drops provides an effective treatment plan for patients with dry eye disease after cataract surgery. It can effectively alleviate dry eye symptoms, reduce eye discomfort, improve tear film stability and ocular surface status, and reduce inflammatory factors in tears.