目的：比较ARK Biometer Combo与OA 2000在配戴角膜塑形镜患者中生物测量的一致性。

方法：前瞻性研究。选取2024年8月至2024年9月于上海市眼病防治中心配戴角膜塑形镜的复诊患者148例148眼，分别应用ARK Biometer Combo和OA 2000进行生物测量，获得眼轴长度(AL)、角膜中央厚度(CCT)、前房深度(ACD)、晶状体厚度(LT)、角膜曲率(Kf和Ks)、散光(AST)、最大角膜横径白到白距离(WTW)、瞳孔直径(PD)等参数。比较两种仪器测量参数的差异，并评估两种仪器的一致性。

结果：两种仪器测量的Kf、Ks、AST均无差异(P>0.05)，测量的AL、CCT、ACD、LT、WTW及PD有差异(t=2.559，P=0.012； t=16.771，P<0.0001； t=4.749，P<0.0001； t=-15.212，P<0.0001； t=-14.915，P<0.0001； t=-2.402，P=0.018)。两种仪器各测量参数的ICC为0.615-0.999。Bland-Altman分析显示两种仪器测量AL、CCT、ACD、LT、Kf、Ks、AST、WTW及PD的95%一致性界限(LoA)最大绝对值分别为0.07 mm、35.07 μm、0.07 mm、0.12 mm、0.66 D、1.14 D、1.00 D、0.76 mm、0.98 mm。

结论：在配戴角膜塑形镜患者中，ARK Biometer Combo和OA 2000测量AL、CCT、ACD、Kf、LT的一致性好，可以相互替换使用。

METHODS: A prospective study. A total of 148 patients(148 eyes)who were wearing orthokeratology lenses and returned for follow-up at the Shanghai Eye Disease Prevention and Treatment Center from August to September 2024 were included. Biometric measurements were performed using both the ARK Biometer Combo and OA 2000. Parameters including axial length(AL), corneal central thickness(CCT), anterior chamber depth(ACD), lens thickness(LT), corneal curvature(Kf and Ks), astigmatism(AST), white-to-white corneal diameter(WTW)and pupil diameter(PD)were obtained. Differences in measurement parameters between the two biometers were compared, and agreement was assessed.

RESULTS: There were no statistically significant differences in the measurements of Kf, Ks and AST between the two biometers(P>0.05). Statistically significant differences were found in the measurements of AL, CCT, ACD, LT, WTW and PD(t=2.559, P=0.012; t=16.771, P<0.0001; t=4.749, P<0.0001; t=-15.212, P<0.0001; t=-14.915, P<0.0001; t=-2.402, P=0.018). ICC ranged from 0.615 to 0.999. Bland-Altman analysis showed that the maximum absolute values of the 95% limits of agreement(LoA)of AL, CCT, ACD, LT, Kf, Ks, AST, WTW and PD were 0.07 mm, 35.07 μm, 0.07 mm, 0.12 mm, 0.66 D, 1.14 D, 1.00 D, 0.76 mm, and 0.98 mm, respectively.

CONCLUSION: In orthokeratology patients, the ARK Biometer Combo and OA 2000 showed good agreement in measuring AL, CCT, ACD, Kf and LT, and can be used interchangeably.