AIM:To investigate the effect of Sanjiemingmu tablet(SJMMT)on inhibiting proliferative vitreoretinopathy(PVR) by testing the contents of interleukin-6(IL-6) in vitreous body and retinal homogenate of modeling rabbits eyes with vitreous hemorrhage and observing hematocele and proliferative membrane.·METHODS:The models of vitreous hemorrhage were induced with autoblood in rabbits eyes and divided into blank control group,model group,positive control group treated with hexuemingmu tablet(HXMMT),and the high,medium,low-dose groups of SJMMT.Hematocele and proliferative membrane was observed by B-scan and the concentration of IL-6 in the vitreous and retinal homo-genate was examined after 6 weeks.·RESULTS:B-scan showed the hematocele absorbing of SJMMT high and medium-dose groups was better than SJMMT low-dose group and HXMMPT group.No proliferative membrane formed.Compared with blank control group,HXMMT group and the high,medium,low-dose groups of SJMMT showed significant difference(P<0.05).Compared with the model group,HXMMT group and the high,medium,low-dose groups of SJMMT showed significant difference(P<0.05).The high and medium-dose groups of SJMMT showes significant diffe-rence with the low-dose group and HXMMT group (P<0.05).·CONCLUSION:SJMMT can accelerate hematocele absor-bing,inhibit organizing trabs and proliferative membrane.