AIM:Selective disturbance of macular Müller cells on the neural retina and retinal vasculature in non-human primates.Try to establish the animal model of idiopathic perifoveal telangiectasis(IPT).·METHODS:Twelve rhesus monkeys (24 eyes) were divided into 6 groups randomly.In the former 3 groups,DL-α-aminoadipic acid (DL-α-AAA) solution 30μL of 5,10,50mmol/L were injected subretinally respectively,one eye for each rhesus monkey,as 3 experimental groups.The control groups were injected subretinally PBS 30μL in other eyes.In the later 3 groups,DL-α-AAA solution 100μL of 16,50,80mmol/L were injected intravitreally respectively,one eye for each rhesus monkey,as 3 experimental groups.The control groups were injected intravitreally PBS 100μL in other eyes.All eyes were examined by fundus color photography,fluorescein an-giography,macular autofluorescence,optical coherence tomography(OCT),multifocal electroretinography(mfERG) and optical microscopy at 1st week before the operation and 6th,12nd week after the operation.·RESULTS:After 6th week of operation,IPT were hap-pened in the groups of subretinal 5mmol/L,10mmol/L and the group of intravitreal 50mmol/L.In the same con-centration groups,corresponding pathological changes were found by OCT and optical microscopy.The group of subretinal 50mmol/L and the group of intravitreal 80mmol/L response a more serious pathological changes,but IPT has not occurred in those groups.·CONCLUSION:DL-α-AAA as ah agent-specific inter-ference of Müller cells in retina,the concentration between subretinal 5mmol/L to 10mmol/L and the concentration intravitreal 50mmol/L could induce IPT.