Meibomian gland carcinoma is a malignant tumor that arises from meibomian glands.It is also the fourth most common malignant neoplasm of the eyelid.Historically,this neoplasm was notorious for masquerading as other benign and less malignant lesions,resulting in delays in diagnosis and treatment.Because these tumors can behave in an aggressive manner,local recurrence and regional lymph node metastasis are common.These factors create difficulties for the early detection and diagnosis.Although based on surgery,cryotherapy,radiation therapy,supplemented by a comprehensive treatment of meibomian gland carcinoma is still the first choice,but with improvements in surgery and radiotherapy methods,meibomian gland carcinoma-related gene discovery,local use of chemotherapy drugs have become possible,as well as the emergence of photodynamic therapy and so on for the treatment of meibomian gland carcinoma has created endless possibilities.This article makes a brief overview of the recent advances on treatment of meibomian gland carcinoma.