AIM:To appraise the curative effect of prophylactic retinal laser photocoagulation before laser epithelial keratomileusis (LASEK) for medium and high myopia.·METHODS:Mydrin eye-liquid was used to disperse pupils in 279 patients (551 eyes) with medium and high myopia before LASEK.Eyeground was examined carefully with 90D slit-light preset lens or three-mirror lens.It’s found that there’s obvious retinal degeneration in 18 cases of 26 eyes with grid style degeneration,snail style degeneration,bursa style degeneration and so on,or dry retinal hole at the same time.Double Nd∶YAG 532nm was used to perform laser treatment,and LASEK to correct myopia.·RESULTS:Preventive double Nd∶YAG 532nm was used to cure 18 cases of 26 eyes,after laser photocoagulation,the retinal degeneration and dry hole area have well-closed situation,the pigment patch formed obviously.6-18 months after LASEK surgery,there is no retinal detachment with random visits.·CONCLUSION:As for the eyes with obvious retinal degeneration or (with) dry retinal hole,prophylactic double Nd∶YAG 532nm laser photocoagulation surgery and choice of LASEK surgery to correct myopia are very important measures to prevent the occurrence of rhegmatogenous retinal detachment after excimer laser correction of myopia.