AIM:To investigate the clinical effect of the operation using the hard palate mucosa graft on the repair of the posterior layer of the full-thickness eyelid defects combined with using the eye flap on the repair of the anterior layer of the full-thickness eyelid defects.·METHODS:Eight cases of full-thickness lower eyelid defects caused by tumor resection were reconstructed by transplanting the autologous palatal mucosa combined with eye flap.·RESULTS:Followed up for 8 months or more,all cases of hard palate mucosa graft and the transfer of eye flaps were survived.The appearance and function of the eyelid were all satisfactory to obtain good results.·CONCLUSION:The operation of palate mucosa transplantation combined with the eye flaps repairing the full-thickness lower eyelid defects can be a one-time repair of the defects of skin,tarsus and conjunctiva.The effect has a highly clinical value.·