AIM:To discuss the mechanism,prevention and therapy of the scleral melting after pterygium excision with intraoperative application of mitomycin C(MMC).·METHODS:Seven patients with scleral melting after pterygium excision with MMC were examined and treated with topical drugs or surgery.·RESULTS:Neither history nor positive manifestation of immunological diseases were found by physical examination.But the ischemic,attenuating could be found at the tissue where the pterygium was excised,and the pigment tissue appeared in some patients,even the staphyloma had formed.The topical drugs and surgery were adopted according to the severity of melting.No recurrences were found during the follow-up.·CONCLUSION:To reduce the recurrences after the excision,the assistant treatment can be adopted.But the concentration and the duration of application should be considered,and the overdose of cauterization should be avoided to assure the enough blood supply at the wound.