AIM:To observe the limbal stem cell transplantation and amniotic membrane transplantation for treatment of pterygium.·METHODS:A total of 126 cases (142 eyes) with wing-shaped pterygium were randomly divided into A,B group,A group of 64 cases (72 eyes) underwent pterygium excision combined with limbal stem cell transplantation;B group of 62 cases (70 eyes) underwent pterygium excision with amniotic membrane transplantation.1 week,1 month,and 3 months after operation,the growth of grafts,corneal wound healing,corneal new blood tube and pterygium recurrence rate were observed and compared.Postoperative follow-up of 24 months.was conducted.·RESULTS:A and B groups conjunctiva epithelial healing time was (2.6±0.4) day and (3.2±0.7) day,the difference was significant (P<0.05);A group had 2 cases (2 eyes) with pterygium recurrence,the cure rate was 97.1%,the recurrence rate of 2.9%;B group had 9 cases(12 eyes) with pterygium recurrence,the cure rate was 81.8%,the recurrence rate of 18.2%;difference between the two groups was statistically significant (P=0.003).·CONCLUSION:Self limbal stem cell transplantation and amniotic membrane transplantation can be effective in preventing the recurrence of pterygium,with advantages of less trauma,fast repair,mild postoperative symptoms and low recurrence rate.