·AIM:To observe the inhibition effect on rat corneal neovascularizition(CNV)by drug combination of the cordyceps militaris extract(CME)and dexamethasone(Dex).·METHODS:CNV model was induced by alkaline burn of the cornea with 1mol/L NaOH.Forty-eight rats were divided into three groups randomly after modeling,A was model group,B was CME treatment group,and C was combination treatment group.All groups received medication by subconjunctival injection every other day after alkaline burn,group A received saline,group B received 10mg CME,group C also received 10mg CME,and received 0.25g/L Dex eyedrops three times each day,each injection volume was set at 0.1mL.On the 4,8,14 days,CNV was observed,and the expression of vascular endothelial growth factor(VEGF)and it’s mRNA in the cornea were detected.·RESULTS:After modeling,rat CNV of the combination group was significantly reduced than the model control group and CME treatment group,the differences were statistically significant(P<0.05).·CONCLUSION:CME combining with Dex can inhibit alkaline burn-induced CNV growth more effectively.·