·AIM:To observe the features of optical coherence tomography(OCT)in multilobular retinal detachment in acute Vogt-Koyanagi-Harada(VKH)disease.·METHODS:Twenty-four eyes of 12 patients with VKH disease were examined with OCT and(fundus fluorescein angiography,FFA).·RESULTS:OCT revealed serous detachment of retinal neuroepithelia in 24 eyes of 12 patients,and subretinal septa that divided the subretinal space into several compartments.After steroid therapy,the serous detachment and subretinal septa resolved completely.·CONCLUSION:Before therapy,subretinal septa caused multilobular retinal detachment in acute VKH disease.·